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(or psilocybin) is a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolized by the body into psilocin. Buy 4-AcO-DMT for sale

While there are studies done on the use of serotonin 5-HT2A agonists in treating substance/drug use disorders, the neurological basis of these effects has yet to be elucidated. There is an interesting study done on the effects of 4-Aco-DMT on drug-dependent rats and mice, published in the European Journal of Neuroscience (EJN). Buy 4-AcO-DMT for sale

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Chronic use of drugs of abuse produces changes and cellular adaptations in neurons located in the VTA (Ventral Tegmental Area) of the brain, which is part of the dopamine-mediated reward pathway. These adaptations are mediated by BDNF (brain-derived neurotrophic factor) and are associated with the aversive withdrawal motivation that leads to a drug-dependent state. There is growing evidence that suggests that 5-HT2A receptor signaling can regulate the expression of BDNF in the brain. Both 5-HT and TrkB signaling are involved in modulating long-term neuronal survival and plasticity but it is still unknown if these effects occur via a direct 5HT2A/TrkB interaction or downstream interactions between 5HT2A signaling/BDNF signaling.

In a study done with 4-Aco-DMT it was observed that a single administration to the VTA of rats and mice blocks the aversive conditioned response to drug withdrawal as well as the mechanism that switches the drug-naive state to a drug-dependent system.

These studies indicated that 5-HT2A agonists can be used as therapeutic agents to reverse drug dependency and inhibit the aversive withdrawal response.